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. Author manuscript; available in PMC: 2011 Nov 16.
Published in final edited form as: Biochemistry. 2010 Oct 21;49(45):9706–9714. doi: 10.1021/bi100509s

Fig. 4.

Fig. 4

Effect of deletion mutagenesis on the ability of nucleolin to promote the formation of a thermally stable c-MYC G-quadruplex. (A) Melting curves obtained for Pu47 containing the c-MYC G-quadruplex motif after incubation with the various nucleolin deletion mutants, including Nuc-1,2,3,4-RGG. (B) Effect of nucleolin C-terminal deletions on c-MYC G-quadruplex stability. (C) Effect of nucleolin N-terminal deletions on c-MYC G-quadruplex stability. (D) Comparison of the effects that Nuc-1,2-RGG, Nuc-2,3-RGG, and Nuc-3,4-RGG have on c-MYC G-quadruplex stabilization.