Figure 1.

Freeze fracture studies of transmembrane Aβ assemblies. (A) Image of a fractured liposome reconstituted with Aβ and shadowed with platinum–carbon. The small particles represent the external domains of the transmembrane Aβ assemblies and the smoother regions, the center of the phospholipid bilayer. The enclosed images are those illustrated in Fig. 3G. (B) The histogram show the distribution of Aβ assemblies according to their diameter (nm, n = 102). The freeze fracture figure was generated by Dr. G. Zampighi (University of California at Los Angeles School of Medicine, Los Angeles, California, USA).