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. 2008 Feb 5;9(1):205–216. doi: 10.1208/s12249-008-9033-0

Table IV.

Temperature Dependencies of 2- and 3-Acetaminophen Solubility, X 2 (mol frac), in n-Hexane, Water, and n-Octanol

  2-Acetaminophen 3-Acetaminophen
n-Hexane Water n-Octanol n-Hexane Water n-Octanol
t (°C) X 2 × 106 X 2 × 104 X 2 × 103 X 2 × 106 X 2 × 103 X 2 × 102
20 3.69 1.20 4.70 3.73 1.18 3.47
25 4.98 1.34 5.63 5.13 1.58 3.88
30 6.14 1.58 6.41 7.14 1.99 4.42
37 8.46 1.90 8.31 11.8 2.71 5.18
42 10.8 2.14 9.47 17.4 3.31 5.84
A a 2.5 ± 0.4 −0.5 ± 0.3 4.7 ± 0.3 9.5 ± 0.7 7.9 ± 0.4 4.1 ± 0.1
B b 4401 ± 113 2492 ± 81 2961 ± 89 6455 ± 209 4287 ± 117 2194 ± 37
R b 0.999 0.998 0.999 0.998 0.999 0.999
σc 2.18 × 10−2 1.56 × 10−2 1.71 × 10−2 4.00 × 10−2 2.25 × 10−2 7.05 × 10−3

aParameters of the correlation equation: ln X 2 = A − B/T

b R is pair correlation coefficient.

c σ is standard deviation.