Table V.

Thermodynamic Functions of Solubility and Solvation Processes of 2-, 3-, and 4-Acetaminophens in Solvents Studied

Solvent	a (mol frac)	b (kJ mol−1)	c (kJ mol−1)	(kJ mol−1)	(J K−1 mol−1)	d (kJ mol−1)	e (kJ mol−1)	(kJ mol−1)	(J K−1 mol−1)	ζHsolv (%)	ζTSsolv (%)
2-Acetaminophen
n-Hexane	4.98 × 10−6	30.3	36.6 ± 0.9	6.3	21 ± 1	22.5	85.2	62.7	210	57.6	42.4
Water	1.34 × 10−4	22.1	20.7 ± 0.7	−1.4	−4.7 ± 1	30.7	101.1	70.4	236	59.0	41.0
n-Octanol	5.63 × 10−3	12.8	24.6 ± 0.7	11.8	40 ± 1	40.0	97.2	57.2	192	63.0	37.0
3-Acetaminophen
n-Hexane	5.13 × 10−6	30.2	53.7 ± 1.7	23.5	79 ± 1	26.2	56.3	30.1	101	65.2	34.8
Water	1.58 × 10−3	16.0	35.6 ± 0.9	19.6	66 ± 1	40.4	75.4	35.0	117	68.3	31.7
n-Octanol	3.88 × 10−2	8.1	18.2 ± 0.3	10.1	34 ± 1	48.3	92.8	44.5	149	67.6	32.4
4-Acetaminophene
n-Hexane	4.12 × 10−6	30.7	41.9 ± 0.7	11.2	37.6	29.3	76.0	46.7	157	61.9	38.1
Water	1.72 × 10−3	15.8	21.8 ± 0.1	6.0	20.1	44.2	96.1	51.9	174	64.9	35.1
n-Octanol	2.47 × 10−2	6.0f	11.7 ± 0.2	5.7	19.1	54.0	106.2	52.2	175	65.5	34.5

^aThe experimental error within 2%

^bCalculated from the temperature dependence of solubility data

^c

^d

^ePerlovich et al. (4)

^fTaking into account activity coefficient