Table VI.

Thermodynamic Parameters of Transfer Processes^a for 2-, 3-, and 4-Acetaminophens

	(kJ/mol)	(kJ/mol)	(kJ/mol)	ζHtr b (%)	ζTStr c (%)	ɛH d (%)
2-Acetaminophen
n-Hexane → water	−8.2	−15.9	−7.7	−67.4	−32.6	17.8
n-Hexane → n-octanol	−17.5	−12.0	5.5	−68.6	31.4	14.1
Water → n-octanol	−9.3	3.9	13.2	22.8	77.2	–
3-Acetaminophen
n-Hexane → water	−14.2	−18.1	−3.9	−82.3	−17.7	32.1
n-Hexane → n-octanol	−22.1	−35.5	−13.4	−72.6	−27.4	63.1
Water → n-octanol	−7.9	−17.4	−9.5	−64.7	−35.3	–
4-Acetaminophene
n-Hexane → water	−14.9	−20.1	−5.2	−79.4	−20.6	26.4
n-Hexane → n-octanol	−24.7	−30.2	−5.5	−84.6	−15.4	39.7
Water → n-octanol	−9.8	−10.1	−0.3	−97.1	−2.9	–

^a (solvent 1 → solvent 2) = (solvent 2) − (solvent 1) (where Y = G, H, S)

^bζ_{H tr} =

^cζ_{T Str}=

^d ɛ _H = (ΔH _spec/ΔH _non–spec) 100%, where (n-hexane → solvent)/ (n-hexane) (experimental error within 6%)

^ePerlovich et al. (4)