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Critical Solubilities of Six McN-5707 Forms in 0.1 N Hydrochloric Acid, Purified Water and SIF (pH 7.4) at 25°C
| Candidate Form | Solubilities, Expressed as the Free Base Equivalent, mg/mL | ||
|---|---|---|---|
| 0.1 N HCl | Water | SIF, pH 7.4 | |
| Free base | 24.8 | 0.0038 | 0.0045 |
| Phosphate hydrate | 23.7 | 9.14 | 0.0093 |
| Fumarate | 12.7 | 1.75 | 0.0088 |
| Maleate | 8.63 | 3.16 | 0.0120 |
| Tosylate | 0.627 | 0.634 | 0.0067 |
| 2-Napsylate | 0.647 | 0.630 | 0.0072 |
