Table IV.
Comparative Grades for Assessment of Efficiency of Self-microemulsification Based in the Dispersibility, Appearance and Time of Microemulsification
| Composition | Formulation (g) | ||||
|---|---|---|---|---|---|
| ME1 | ME2 | ME3 | ME4 | ME5 | |
| Exemestane | 25 mg | 25 mg | 25 mg | 25 mg | 25 mg |
| Cremophore ELP | 755 mg | 640 mg | 690 mg | 430 mg | 370 mg |
| Transcutol HP | 125 mg | 220 mg | 110 mg | 70 mg | 130 mg |
| Caproyl 90 | 120 mg | 140 mg | 200 mg | 500 mg | 500 mg |
| Assessment of SMEDDS diluted with deionized water | |||||
| Visual observation grade | I | I | I | I/II | I/II |
| Droplet size (after 0.5 h) nm | 12.3 | 14.1 | 25.6 | 28.5 | 31.0 |
| Polydispersity index (after 0.5 h) | 0.11 | 0.23 | 0.08 | 0.06 | 0.02 |
| Zeta potential (after 0.5 h) mv | −2.2 | −7.3 | −0.7 | −9.7 | −5.4 |
| Droplet size (after 24 h) nm | 12.8 | 14.3 | 27 | 29.6 | 32.3 |
| Polydispersity index (After 24 h) | 0.04 | 0.05 | 0.37 | 0.09 | 0.08 |
| Zeta potential (after 24 h) mv | −1.8 | −7.1 | −0.9 | −10.8 | −4.2 |
| Assessment of SMEDDS diluted with 0.1 N HCl | |||||
| Visual observation grade | I | I | I | I/II | II |
| Droplet size (after 0.5 h) nm | 14.1 | 13.7 | 22.9 | 28.1 | 30.1 |
| Polydispersity index (after 0.5 h) | 0.07 | 0.01 | 0.08 | 0.23 | 0.18 |
| Zeta potential (after 0.5 h) mv | −2.7 | −6.9 | −1.0 | −10.6 | −5.9 |
| Droplet size (after 24 h) nm | 15.3 | 16.3 | 28.1 | 29.2 | 32.8 |
| Polydispersity index (after 24 h) | 0.11 | 0.15 | 0.08 | 0.03 | 0.34 |
| Zeta potential (after 24 h) mv | −2.9 | −7.8 | −1.6 | −11.8 | −4.1 |