Table 4.

Effect of Different Enhancers on the Flux, Lag Time and Correlation Coefficients According to Zero Order and Higuchi’s Plots of Diltiazem HCl Films (HPMC/EC ratio, 8:2)

Enhancers	Fluxa (μg/cm2.h)	Lag timea (h)	r 2 zero order plota	r 2 Higuchi’s plota
IPMb	228 ± 17	1.67	0.998 ± 0.003	0.995 ± 0.006
IPPb	238 ± 109	1.39	0.998 ± 0.004	0.996 ± 0.006
NMPb	125 ± 13	2.93	0.989 ± 0.007	0.959 ± 0.013
OAc	90 ± 16	3.02	0.931 ± 0.037	0.877 ± 0.048
PEGb	144 ± 59	2.63	0.978 ± 0.034	0.940 ± 0.050
PGc	89 ± 19	2.82	0.939 ± 0.038	0.889 ± 0.057
Tween80b	169 ± 23	0.03	0.971 ± 0.023	0.995 ± 0.011

^aCalculated from time range of 3–12 h

^b n = 4

^c n = 5