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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: Biochem Pharmacol. 2010 Jun 23;80(12):2050–2056. doi: 10.1016/j.bcp.2010.06.019

Figure 3.

Figure 3

Molecule 8 inhibits the formation of the [[3H]LOS-MD-2-TLR4ECD]2 complex. The incubation mixture containing [3H]-LOSagg, LBP, sCD14 and MD-2-TLR4ECD ± the synthetic compound (10 μM) were analyzed by gel-sieving analysis using a Sephacryl S300 as described in Materials and Methods section. Profiles shown are representative of 3 experiments for each condition (both in presence or absence of molecule 8).