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In Situ Perfusion
| Parameters to standardize | • Animal species and age |
| • Fed/fast status of animal | |
| • Anesthesia regimen | |
| • Time to equilibrium | |
| • Intestinal region | |
| • Perfusion buffer composition, osmolarity and pH | |
| • Perfusion rate | |
| • Drug analysis and P eff calculation | |
| Acceptance criteria | • P eff of non-absorbable marker |
| • P eff of HP marker | |
| • P eff of active transport marker |
