Fig. 3.

The intensities of fenofibrate (1,580–1,610 cm⁻¹), mannitol (865–895 cm⁻¹), and water (208–226 cm⁻¹) peaks and the peak width of TBA (725–763 cm⁻¹) during the first 1,000 min of process 1. During this process the freeze-drier shelf was cooled during the first 70 min from 20°C to −50°C, then the temperature was kept constant at −50°C for 120 min, then the temperature of the freeze-drier shelf was increased to −25°C in 30 min and kept constant for 420 min. Finally, the pressure was decreased to 0.8–1.0 mBar to dry the samples