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Time and relative concentration profiles of AMG531 in rat serum samples after i.v. dosing of AMG531 and 125I-AMG531 at 0.3 mg/kg: LBA1 (open circles), LBA2 (filled circles), and radioassay (filled triangles). The radioassay CPM were not converted to equivalent concentration due to the lack of accurate radiospecificity. Therefore, the levels were normalized by the 1-h CPM (20,400) for radioassay or 1-h concentrations for LBA1 and LBA2 (3,230 and 3,420 ng/mL, respectively)
