Table II.
Composition of Three-Layered Tablets Containing 200-mg in Middle Layer of 1:1 Chitosan and Xanthan Gum and 75% other Diluents and (B) 55% Lactose and 20% Other Diluents
| Substances | Formulation (%,w/w) | ||||
|---|---|---|---|---|---|
| A75 | B75 | C75 | D75 | E75 | |
| Propranolol HCl | 20 | 20 | 20 | 20 | 20 |
| Chitosan | 9.75 | 9.75 | 9.75 | 9.75 | 9.75 |
| Xanthan gum | 9.75 | 9.75 | 9.75 | 9.75 | 9.75 |
| Lactose | 58.5 | ||||
| Microcrystalline cellulose | 58.5 | ||||
| PEG 4000 | 58.5 | ||||
| Phytowax | 58.5 | ||||
| Ethyl cellulose | 58.5 | ||||
| Magnesium stearate | 2 | 2 | 2 | 2 | 2 |
With the 100-mg upper and 100-mg lower barriers of the same formula without drug