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. 2008 Aug 28;9(3):982–990. doi: 10.1208/s12249-008-9136-7

Table I.

First-Order Degradation Rate Constants (k), Degradation Half-Lives (t 1/2) and Solubility of THC-HG at 25°C in Buffers of Various pH Values

pH k (h−1) t 1/2 (days) Solubility (μg/mL)
2.4 0.0051 5.66
3.0 0.0014 20.63 +
4.0 0.0016 18.05 +
5.0 2.52
6.0 0.0069 4.18 6.12
7.0 0.0094 3.07 17.29
8.0 0.0121 2.39 539.56
10.0 411.34

− Study not performed at that condition, + No detectable THC-HG peak observed