Table V.
Mean Pharmacokinetic Parameters of Carbamazepine Obtained After Oral Administration of Tegretol® CR, Formula F and L to Beagle Dogs
| Parameters | Products | ||
|---|---|---|---|
| Tegretol® CR | Formula F | Formula L | |
| AUC0–72 h (μg.h.ml−1) | 23.1 ± 9.561 (10.69–31.91) | 26.14 ± 11.705 (15.00–46.16) | 34.25 ± 10.43 (25.36–55.74) |
 (μg.h.ml−1) |
25.27 ± 10.44 (11.59–34.61) | 30.091 ± 10.496 (18.70–48.92) | 36.34 ± 10.67 (26.26–59.08) |
| C max (μg ml−1) | 1.38 ± 0.49 (0.91–2.09) | 1.352 ± 0.549 (0.76–2.01) | 2.18 ± 0.68 (1.34–3.18) |
| t max a (h) | 6.00 (4–10) | 7.00 (6–8) | 8.00 (6–10) |
| MRT (h) | 21.43 ± 4.57 (13.22–26.21) | 34.091 ± 9.749 (23.94–47.35) | 23.76 ± 5.17 (17.25–32.19) |
| t lag (h) | 0.68 ± 0.26 (0.34–1.0) | 0.58 ± 0.31 (0.12–0.91) | 0.57 ± 0.10 (0.41–0.69) |
| F rel(%)b | 119.1 | 143.8 | |
Values in parenthesis are range of data (n = 6)
aMedian data
bRelative bioavailability