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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Hepatology. 2010 Jan;51(1):246–254. doi: 10.1002/hep.23267

Figure 1.

Figure 1

Plasma alanine aminotransferase (ALT) activities and the hepatic content of glutathione (GSH+GSSG) and glutathione disulfide (GSSG) were measured in control animals or mice treated with 300 mg/kg acetaminophen (APAP) for 6 h. The ratio between GSSG and total glutathione was calculated. Some of the animals received additionally 10 ml/kg saline, 0.65 mmol/kg GSH or 0.65 mmol/kg N-acetylcysteine (NAC) iv 1.5 h after APAP. Data represent means ± SE of n = 5 animals per group. *P<0.05 (compared to controls); #P<0.05 (compared to APAP/saline)