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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Hepatology. 2010 Jan;51(1):246–254. doi: 10.1002/hep.23267

Figure 2.

Figure 2

Histological assessment of liver injury (hematoxilin & eosin, H&E), peroxynitrite formation (nitrotyrosine staining) and DNA fragmentation (TUNEL assay) in control animals or mice treated with 300 mg/kg acetaminophen (APAP) for 6 h. Some of the animals received additionally 10 ml/kg saline, 0.65 mmol/kg GSH or 0.65 mmol/kg N-acetylcysteine (NAC) iv 1.5 h after APAP. The representative pictures show extensive centrilobular necrosis, which correlated with the areas of nitrotyrosine staining and TUNEL-positive cells in APAP-treated animals. Both, GSH and NAC treatment improved all parameters with GSH being more effective than NAC. (×100 for all panels)