TABLE 5.
Serum neutralizing antibodies elicited in mice and ferrets following 1 or 2 doses of H7N7 NL/03 ca vaccinea
| Species | No. of doses | No. of days postimmunization | Reciprocal GMT of serum neutralizing antibody against indicated wt virusb |
|||
|---|---|---|---|---|---|---|
| H7N7 NL/03 | H7N3 ck/BC/04 | H7N3 tk/EG/63 | H7N1 tk/Italy/99 | |||
| Mouse | 1 | 28 | 14 | 24 | 21 | 22 |
| 2 | 56 | 191 | 285 | 153 | 160 | |
| Ferret | 1 | 28 | 12 | 10 | 15 | ND |
| 2 | 56 | 41 | 54 | 80 | ND | |
a
Mice and ferrets received one or two intranasal doses of 106 TCID50 and 107 TCID50 of the immunizing virus, respectively.
b
Values represent reciprocal geometric mean antibody titers from four mice and three ferrets per group. Antibodies were not detected in preimmunization sera and in sera from mock-immunized mice and ferrets. An undetectable serum neutralizing antibody titer was assigned a value of 10. Homologous antibody titers are in boldface type. ND, not done.