TABLE 6.

Immunogenicity and efficacy of the H7N7 NL/03 ca vaccine in African green monkeys^a

Vaccine	Animal	Prechallenge serum antibody titerb		Titer of challenge virus in respiratory tissues (log10TCID50/g)			Titer of challenge virus in respiratory secretions (log10TCID50/ml)
		HAI	NT	Nasal turbinates	Trachea	Lungs	Nasal/pharyngeal swabs	Nasal wash specimens	Tracheal lavage fluid
L-15	1	<1:20c	<1:2d	6	6.7	4.1 ± 2.1e	1.0	5.7	5.4
H7N7 NL/03 ca	2	1:80	1:128	<1.5f	<1.5	<1.5	<0.5g	<0.5	<0.5
H7N7 NL/03 ca	3	<1:20	1:64	3.4	4.7	2.8 ± 1.7	<0.5	<0.5	<0.5
H7N7 NL/03 ca	4	<1:20	1:16	<1.5	4.3	4.7 ± 2.4	<0.5	<0.5	<0.5

^aAGMs were immunized with a single dose of vaccine and were challenged with the H7N7 NL/03 wt virus 8 weeks later, and tissues were harvested 2 days following challenge.

^bSera collected 8 weeks after immunization.

^cLowest dilution of serum tested in an HAI assay.

^dLowest dilution of serum tested in an MN assay.

^eMean titer from eight lung samples ± SE.

^fDetection limit in tissues.

^gDetection limit in secretions.