TABLE 4.
Properties of HVEM ligands
| Ligand | Affinitya | Oligomerb | HVEM downregulationc |
|---|---|---|---|
| gD(306t) | + | 2 | ++d |
| gD(285t) | +++ | 2 | NAe |
| BTLA | ++ | 1 | +++ |
| LIGHT | ++++ | 3 | ++ |
| LTα | +++ | 3 | NA |
| CD160 | ++ | 1 | +/− |
| gD(W294A) | +++ | 2 | +++ |
a
KD summarized according to Table 2.
b
Number of protomers in the soluble proteins used in this study. On the cell surface, BTLA is likely a dimer and CD160 forms multimers (10, 21).
c
Determined in cocultures with HVEM ligands expressed on the surface of effector cells.
d
Downregulation by full-length wt gD.
e
NA, not applicable. gD285t and LTα(r) are soluble proteins.