FIG. 4.
Denatured fractions of PrPSc after treatment with 1.5 M or 2 M GdnHCl. Frontal cortex samples obtained from 10 vCJD and 10 sCJD MM1 subtype cases were treated with different concentrations of GdnHCl (0 M, 1.5 M, 2 M, and 7 M) and tested by CDI. The denatured fraction of PrPSc in each concentration of GdnHCl was calculated, and the results for individual cases were plotted against the concentration of GdnHCl. The results for the vCJD cases are depicted as gray diamonds, and the results for the sCJD MM1 cases are depicted as black diamonds.