Daily clinical scores after challenge infection with HPAIV H5N1. The animals were observed daily for a period of 10 days for clinical signs and scored as follows: healthy (score of 0), reduced activity (score of 0.25), slightly ill (score of 0.5), ill (score of 1), severely ill (score of 2), or dead (score of 3). A daily clinical index (CI) was calculated, which represents the mean value for all chickens per group for the given day.