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. Author manuscript; available in PMC: 2010 Nov 10.
Published in final edited form as: J Comput Chem. 2008 Apr 15;29(5):788–794. doi: 10.1002/jcc.20839

Table 1.

Number of observed temperature crosswalks per walker with the nearest neighbor (synchronous algorithm) and non-nearest neighbor (asynchronous algorithm) schemes as a function of the number of replicas.

Exchange Scheme Number of Replicas
8 16 32 64
Nearest neighbor 109 143 104 19

Non-nearest neighbor 79 150 196 190