Table 1.

In vivo low dose drug cocktail phenotyping for assessment of drug-metabolizing cytochrome P450 (CYP) enzymes including selective substrates employed, respective doses and phenotyping parameters.

Drug-metabolizing CYP enzymes	Drug	Dose (mg)	Phenotyping parameter (unit)
CYP1A2	Caffeine	150	Oral caffeine clearance (ml/min per kg body weight)
CYP2C9	Tolbutamide	125	Plasma concentration of tolbutamide 24 h post dose (μg/ml)
CYP2C19	Omeprazole	20	Ratio of the molar plasma concentrations of omeprazole over 5-hydroxyomeprazole 3 h post dose (−)
CYP2D6	Dextromethorphan hydrobromide	30	Ratio of the molar plasma concentrations of dextromethorphan over dextrorphan 3 h post dose (−)
CYP3A4	Midazolam	2	Oral midazolam clearance (L/hl)