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. Author manuscript; available in PMC: 2011 Oct 15.
Published in final edited form as: Cancer Res. 2010 Aug 31;70(20):7992–8002. doi: 10.1158/0008-5472.CAN-10-0585

Figure 2. Microtubule Targeting Drugs Inhibit Ligand-dependent AR Transcriptional Activity.

Figure 2

LNCaP cells were treated with DHT (1nM) in the presence or absence of Nocodazole (5ug/ml) or Paclitaxel (1μM). Panel A; PSA mRNA expression was determined by realtime PCR. Panel B; PSA protein levels were assessed by Western blotting and relative expression was quantitated (lower panel). Panel C; The AR transcriptional activity in response to microtubule-targeting drugs was determined using the ARE luciferase reporter vector in LNCaP cells.