Table 1.
Summary of Experimental Studies to Evaluate Sigmodon hispidus and Sigmodon fulviventer as a Model for SARS Disease
| Experiment | Species (n)a | Signsb | Weight lossc | Virus isolationd | IHCe | Pathologyf | Antibodyg |
|---|---|---|---|---|---|---|---|
| 1 | S. hispidus (16) | None | Not done | Not done | Neg | Not done | Not done |
| 2 | S. hispidus (15) | None | None | Positive | Neg | None | Negative |
| 3 | S. fulviventer (12) | None | Not done | Negative | Neg | Not done | 1/80 to 1/360 |
| 4 | S. fulviventer (20) | None | None | Negative | Neg | Positive | 1/40 to 1/160 |
a
Experiment number/species (number of animals).
b
Signs of illness.
c
Not weighted; weighed daily and no loss seen.
d
10% of organ homogenates tested at sensitivity of 100 TCID50.
e
Immunohistochemical, neg = no viral antigen detected.
f
Histopathological examination detected no lesions in S. hispidus and inconsistent mild lesions in S. fulviventer lung compared to controls.
g
Serum collected on days 21–22 post-inoculation had neutralization titers as indicated.