Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Nov;27(11):2067–2076. doi: 10.1089/neu.2010.1403

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright 2010, Mary Ann Liebert, Inc.

PMC Copyright notice

FIG. 3. — Magnetic resonance imaging (MRI) analysis of lesion volume and blood–spinal cord barrier permeability at 56 days post-injury. (A) T2-weighted RARE image of a typical injured spinal cord showing the hyperintense region (black asterisk) indicating edema and demyelination, and the hypointense region (white asterisk) indicating hemorrhage and necrosis. (B) A significant decrease in the hyperintense lesion volume was observed in the AAV-Ang-1- and AAV-VEGF₁₆₅/Ang-1-treated groups. Error bars represent standard deviations (*p = 0.0105). (C) No significant decrease was observed in the hypointense lesion volume. (D) A significant decrease in the percentage of enhanced area as determined by dynamic contrast imaging was observed in the AAV-VEGF₁₆₅/Ang-1 animals, indicating a reduced general compromise of the blood–spinal cord barrier compared to viral controls. Error bars represent standard deviations (*p = 0.0046; VEGF₁₆₅, vascular endothelial growth factor-165; Ang-1, angiopoietin-1; AAV, adeno-associated virus; RARE, rapid acquisition by relaxation enhancement).