Table 1.

Cotswold Modification of the Ann Arbor Staging for HL

Stage	Description
I	Involvement of a single lymph node region or lymphoid structure
II	Involvement of ≥ two lymph node regions on the same side of the diaphragm
III	Involvement of lymph node regions on both sides of the diaphragm
	III1 With or without involvement of splenic, hilar, celiac, or portal nodes
	III2 With involvement of para-aortic, iliac, and mesenteric nodes
IV	Diffuse or disseminated involvement of one or more extranodal organs or tissues, with or without associated lymph node involvement
A	No symptoms
B	Fever (temperature, >38°C [100.4°F]), drenching night sweats, unexplained loss of >10% of body weight within the preceding 6 months
X	Bulky disease (a widening of the mediastinum by more than one-third due to presence of a nodal mass with a maximal dimension greater than 10 cm)
E	Involvement of a single extranodal site that is contiguous or proximal to the known nodal site
CS	Clinical stage
PS	Pathologic stage