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. Author manuscript; available in PMC: 2011 Nov 11.

Published in final edited form as: J Med Chem. 2010 Nov 11;53(21):7804–7824. doi: 10.1021/jm100947x

Table 1.

Inhibition of NOS isozymes by 1–7.

Compounds	K_i (μM)			Selectivity^a
Compounds	nNOS	eNOS	iNOS	n/e	n/i
(±)-1	0.388	434.5	58.4	1114	150
(±)-2	0.085	85	8.95	1000	106
(±)-3	0.014	28	4.06	2000	290
(±)-4	0.015	31	9.5	2067	633
(±)-5	8.76	866.2	77.4	99	9
(±)-6	13.28	85.2	143.8	6	11
(±)-7	28.54	683.7	233.8	24	8

^a

n/e and n/i are the selectivity ratio of K_i (eNOS or iNOS) to K_i (nNOS).