Table 1.
Diagnostic criteria used in the population screening for hereditary cancer.
| Hereditary syndrome | Diagnostic criteria |
|---|---|
| Hereditary non-polyposis colorectal cancer, group 1a (HNPCC/g1) | Amsterdam II criteria [15] |
| HNPCC, group 2 (HNPCC/g2) | At least 2 first degree relatives with HNPCC associated cancer (colorectal, endometrial, small bowel, ureteric, renal pelvis) and at least one cancer diagnosed before age 50 |
| Familial colorectal cancer, group 2 (FCC/g2) | Colorectal cancer in at least two first or second degree relatives. HNPCC and familial adenomatous polyposis should be excluded |
| Hereditary breast cancer, group 1 (HBC/g1) | At least 3 breast cancer patients in family and one of those patients is first degree relative to other two or second degree relative through male |
| Hereditary breast cancer, variety 1, group 2 (HBC1/g2) | At least one of the following criteria: 1) Breast cancer diagnosed under the age of 40; 2) Medullary or atypical medullary breast cancer; 3) Male breast cancer; 4) Bilateral breast cancer, one of them diagnosed under the age of 50. |
| Hereditary breast cancer, variety 2, group 2 (HBC2/g2) | Two breast cancer cases among first degree relatives (or second degree through male) |
| Hereditary ovarian cancer, group 1 (HOC/g1) | At least 3 ovarian cancer cases in family and one of those patients is first degree relative to other two or second degree relative through male |
| Hereditary ovarian cancer, group 2 (HOC/g2) | Two ovarian cancer cases among first degree relatives |
| Hereditary breast-ovarian cancer, group 1 (HBOC/g1) | At least 3 breast or ovarian cancer patients in family at any age and one of those patients is first degree relative to other two or second degree relative through male |
| Hereditary breast-ovarian cancer, variety 1, group 2 (HBOC1/g2) | Breast and ovarian cancer in the same individual at any age |
| Hereditary breast/ovarian cancer, variety 2, group 2 (HBOC2/g2) | One breast cancer diagnosed under the age of 50 and one ovarian cancer diagnosed at any age among first degree relatives or second degree relatives through male |
| Hereditary endometrial cancer, group 1 (HEC/g1) | At least 3 first degree relatives with endometrial cancer and at least one of them diagnosed before age of 50 |
| Hereditary endometrial cancer, group 2 (HEC/g2) | Two first degree relatives with endometrial cancer and at least one of them diagnosed before age of 50 |
| Familial endometrial cancer, group 1 (FEC/g1) | At least 3 first degree relatives with endometrial cancer. HEC/g1 should be excluded |
| Familial endometrial cancer, variety 1, group 2 (FEC1/g2) | At least 2 first degree relatives with endometrial cancer. HEC/g2 should be excluded |
| Familial endometrial cancer, variety 2, group 2 (FEC2/g2) | At least 2 second degree relatives with endometrial cancer |
| Familial lung cancer, group 1 (FLC/g1) | At least 3 first degree relatives with lung cancer |
| Familial lung cancer, group 2 (FLC/g2) | Two first degree relatives with lung cancer |
| Hereditary gastric cancer, group 1 (HGC/g1) | At least 3 first degree relatives with gastric cancer |
| Hereditary gastric cancer, group 2 (HGC/g2) | Two first degree relatives with gastric cancer |
| Hereditary prostate cancer, group 1 (HPC/g1) | At least 3 blood relatives with prostate cancer at any age or 2 blood relatives with prostate cancer diagnosed before age of 55 in both of them |
| Hereditary prostate cancer, group 2 (HPC/g2) | Two blood relatives with prostate cancer at any age or a case of prostate cancer diagnosed before age of 55 |
| Familial brain tumour, group 1 (FBT/g1) | At least 3 first degree relatives with brain tumour |
| Familial brain tumour, group 2 (FBT/g2) | Two first degree relatives with brain tumour |
| Familial malignant haematological tumour, group 1 (FHemT/g1) | At least 3 first degree relatives with malignant haematological tumour |
| Familial malignant haematological tumour, group 2 (FHemT/g2) | Two first degree relatives with malignant haematological tumour |
| Familial pancreatic tumour, group 1 (FPan/g1) | At least 2 first degree relatives with pancreatic tumour or melanoma |
| Familial urinary bladder cancer, group 1 (FBlaC/g1) | At least 3 first degree relatives with urinary bladder cancer |
| Familial urinary bladder cancer, group 2 (FBlaC/g2) | Two first degree relatives with urinary bladder cancer |
| Other familial cancer syndromes | At least 3 first degree relatives with concordant cancer |
agroups 1 and 2 were defined for the use solely within the presented study