Table 2.
Estimated OR of uveal melanoma associated with the occupational group of cooks in Germany
| Population control subjects | Ophthalmologists control subjects | Sibling control subjects | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Control subjects, n | Case patients, n | OR1 (95% CI) | Control subjects, n | Case patients, n | OR2 (95% CI) | Control subjects, n | Case patients, n | OR3 (95% CI) | |
| Germany | (n = 827) | (n = 455) | (n = 180) | (n = 133) | (n = 187) | (n = 187) | |||
| Cooks according to ISCO (5-31.20-5-31.90) | |||||||||
| No | 802 | 442 | 1.0 | 170 | 131 | 1.0 | 179 | 185 | 1.0 |
| Yes | 25 | 13 | 1.1 (0.5-2.1) | 10 | 2 | 0.3 (0.1-1.6) | 8 | 2 | 0.1 (0.02-1.2) |
| Male cooks | |||||||||
| No | 446 | 239 | 1.0 | 101 | 78 | < | 80 | 96 | < |
| Yes | 8 | 2 | 0.6 (0.1-3.1) | 2 | 0 | 1 | 0 | ||
| Female cooks | |||||||||
| No | 356 | 203 | 1.0 | 69 | 53 | 1.0 | 99 | 89 | 1.0 |
| Yes | 17 | 11 | 1.2 (0.6 - 2.7) | 8 | 2 | 0.4 (0.1-1.9) | 7 | 2 | 0.3 (0.03-2.2) |
| Cooks and duration of job period (years) | |||||||||
| Never | 802 | 442 | 1.0 | 170 | 131 | 1.0 | 179 | 185 | 1.0 |
| 0,5-2 | 7 | 3 | 0.9 (0.3-3.7) | 4 | 0 | < | 3 | 0 | < |
| >2 | 17 | 10 | 1.2 (0.5-2.6) | 6 | 2 | 0.4 (0.1-2.5) | 5 | 2 | 0.3 (0.03-2.2) |
| Missing | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Cooks according to ISCO (5-31.20-5-31.90) who actually cooked | |||||||||
| No | 808 | 447 | 1.0 | 174 | 132 | 1.0 | 180 | 185 | 1.0 |
| Yes | 19 | 8 | 0.9 (0.4-2.1) | 6 | 1 | 0.3 (0.04-2.7) | 7 | 2 | 0.2 (0.02-1.4) |
| Male cooks | |||||||||
| No | 446 | 240 | 1.0 | 101 | 78 | n.e* | 80 | 96 | n.e* |
| Yes | 8 | 1 | 0.3 (0.03-2.4) | 2 | 0 | 1 | 0 | ||
| Female cooks | |||||||||
| No | 362 | 207 | 1.0 | 73 | 54 | 1.0 | 100 | 89 | 1.0 |
| Yes | 11 | 7 | 1.3 (0.5 - 3.5) | 4 | 1 | 0.4 (0.04-3.9) | 6 | 2 | 0.3 (0.04-3.2) |
| Cooks and duration of job period (years) | |||||||||
| Never | 808 | 447 | 1.0 | ||||||
| 0,5-2 | 4 | 1 | 0.7 (0.1-6.5) | ||||||
| >2 | 15 | 7 | 0.9 (0.4-2.3) | ||||||
OR - odds ratio; conditional logistic regression with matching factors and 95% CI-95% confidence interval.
OR1 = Odds Ratio of population controls, OR2 = OR of ophthalmology controls, OR3 = OR of sibling controls. Matching factors for the conditional analysis were age (5-year age groups), sex, and geographic area by population controls, age (5-year age groups) and sex by ophthalmologist controls, and only age (+/-10 years) by sibling controls.
* n.e. not estimated