Table 4.
Gf enhancement differentiates between EAE animals and healthy controls
| Choroid plexus | SFO | AP | |
|---|---|---|---|
| Area under the ROC curve | 0.90 | 0.81 | 0.84 |
| Standard error (95% CI) | 0.07 (0.77 to 1.03) | 0.09 (0.64 to 0.98) | 0.08 (0.68 to 1.01) |
| P value (two-tailed) | 0.007 | 0.018 | 0.014 |
| Significance | ** | * | * |
| Cutoff MIR | >0.9826 | >1.232 | >1.189 |
| Sensitivity (95% CI) | 89% (65 to 99%) | 67% (41 to 87%) | 82% (57 to 96%) |
| Specificity (95% CI) | 80% (28 to 100%) | 86% (42 to 100%) | 83% (36 to 100%) |
| Likelihood ratio | 4.44 | 4.67 | 4.94 |
ROC analysis of the Gf enhancement (mean intensity ratios) in circumventricular organs, differentiating between EAE animals and controls. Exemplary cut-off values and the resulting sensitivity, specificity and likelihood ratio are presented for each region
ROC: receiver operating characteristic; SFO: subfornicular organ; AP: area postrema; *: P value < 0.05; **: P value < 0.01; MIR: mean intensity ratio; CI: confidence interval