Table 3.
KIR gene alleles of the telomeric LD region tagging other KIR genes alleles
| KIR tagging allele | KIR tagged allele | PPV | NPV | Haplotype Frequency | D′ (*) | |
|---|---|---|---|---|---|---|
| KIR2DL4 | *011 | KIR3DL1/S1*005 | 100.00% | 99.70% | 13.60% | 0.21 |
| *011 | KIR2DS4*003 | 100.00% | 72.30% | 13.60% | 0.49 | |
| *011 | KIR3DL2*001 | 77.20% | 85.90% | 10.50% | 0.27 | |
| *00802 | KIR2DS4*006 | 98.60% | 99.40% | 16.70% | 0.49 | |
| *00802 | KIR3DL1/S1*004 | 95.80% | 99.70% | 16.30% | 0.21 | |
| *00801 | KIR2DS4*003 | 94.90% | 75.60% | 17.70% | 0.49 | |
| *00801 | KIR3DL1/S1*00101 | 89.70% | 99.70% | 16.70% | 0.21 | |
| *00501 | KIR3DL1/S1*013 | 93.80% | 99.70% | 18.20% | 0.21 | |
| *00501 | KIR3DL2*007 | 95.10% | 97.60% | 18.40% | 0.27 | |
| *00501 | KIR2DS1*002 | 100.00% | 97.60% | 19.40% | 0.71 | |
| *00501 | KIR2DS5*002 | 82.70% | 98.80% | 16.00% | 0.86 | |
| *00501 | KIR2DL5A*001 | 79.00% | 99.40% | 15.30% | 0.69 | |
| *00103 | KIR3DL2*009 | 81.30% | 99.20% | 6.20% | 0.27 | |
| *00103 | KIR3DL1/S1*008 | 75.00% | 100.00% | 5.70% | 0.21 | |
| *00103 | KIR2DS4*003 | 71.90% | 65.30% | 5.50% | 0.49 | |
| *00102 | KIR3DL2*002 | 100.00% | 99.10% | 17.50% | 0.27 | |
| *00102 | KIR2DS4*00101 | 98.60% | 96.80% | 17.20% | 0.49 | |
| KIR3DL1/S1 | *01502 | KIR3DL2*002 | 100.00% | 89.30% | 8.40% | 0.25 |
| *01502 | KIR2DL4*00102 | 100.00% | 90.10% | 8.40% | 0.21 | |
| *01502 | KIR2DS4*00101 | 97.10% | 87.20% | 8.10% | 0.47 | |
| *013 | KIR3DL2*007 | 94.80% | 96.50% | 17.50% | 0.25 | |
| *013 | KIR2DL4*00501 | 98.70% | 98.50% | 18.20% | 0.21 | |
| *013 | KIR2DS1*002 | 100.00% | 96.50% | 18.40% | 0.71 | |
| *013 | KIR2DS5*002 | 81.80% | 97.70% | 15.10% | 0.84 | |
| *013 | KIR2DL5A*001 | 77.90% | 98.20% | 14.40% | 0.69 | |
| *008 | KIR2DS4*003 | 95.80% | 66.00% | 5.50% | 0.47 | |
| *008 | KIR2DL4*00103 | 100.00% | 98.00% | 5.70% | 0.21 | |
| *005 | KIR2DL4*011 | 98.30% | 100.00% | 13.60% | 0.21 | |
| *005 | KIR2DS4*003 | 98.30% | 72.20% | 13.60% | 0.47 | |
| *005 | KIR3DL2*001 | 75.90% | 85.80% | 10.50% | 0.25 | |
| *004 | KIR2DL4*00802 | 98.60% | 99.10% | 16.30% | 0.21 | |
| *004 | KIR2DS4*006 | 98.60% | 98.90% | 16.30% | 0.47 | |
| *002 | KIR3DL2*002 | 100.00% | 89.50% | 8.60% | 0.25 | |
| *002 | KIR2DL4*00102 | 100.00% | 90.30% | 8.60% | 0.21 | |
| *002 | KIR2DS4*00101 | 100.00% | 87.70% | 8.60% | 0.47 | |
| *00101 | KIR2DL4*00801 | 98.60% | 97.70% | 16.70% | 0.21 | |
| *00101 | KIR2DS4*003 | 95.80% | 74.40% | 16.30% | 0.47 | |
| KIR2DL5A | *001 | KIR3DL1/S1*013 | 90.90% | 95.20% | 14.40% | 0.69 |
| *001 | KIR3DL2*007 | 95.50% | 93.80% | 15.10% | 0.8 | |
| *001 | KIR2DL4*00501 | 97.00% | 95.20% | 15.30% | 0.69 | |
| *001 | KIR2DS1*002 | 100.00% | 93.50% | 15.80% | 0.85 | |
| *001 | KIR2DS5*002 | 100.00% | 98.60% | 15.80% | 0.83 | |
| KIR2DS5 | *002 | KIR3DL1/S1*013 | 88.70% | 96.00% | 15.10% | 0.84 |
| *002 | KIR3DL2*007 | 95.80% | 95.10% | 16.30% | 0.84 | |
| *002 | KIR2DL4*00501 | 94.40% | 96.00% | 16.00% | 0.86 | |
| *002 | KIR2DS1*002 | 100.00% | 94.80% | 17.00% | 0.87 | |
| *002 | KIR2DL5A*001 | 93.00% | 100.00% | 15.80% | 0.83 | |
| KIR2DS1 | *002 | KIR3DL1/S1*013 | 86.50% | 100.00% | 18.40% | 0.71 |
| *002 | KIR3DL2*007 | 92.10% | 99.10% | 19.60% | 0.86 | |
| *002 | KIR2DL4*00501 | 91.00% | 100.00% | 19.40% | 0.71 | |
| *002 | KIR2DS5*002 | 79.80% | 100.00% | 17.00% | 0.87 | |
| *002 | KIR2DL5A*001 | 74.20% | 100.00% | 15.80% | 0.85 | |
| KIR2DS4 | *006 | KIR2DL4*00802 | 97.20% | 99.70% | 16.70% | 0.49 |
| *006 | KIR3DL1/S1*004 | 94.40% | 99.70% | 16.30% | 0.47 | |
| *00101 | KIR3DL2*002 | 89.20% | 99.40% | 17.70% | 0.62 | |
| *00101 | KIR2DL4*00102 | 86.70% | 99.70% | 17.20% | 0.49 | |
| KIR3DL2 | *011 | KIR2DL4*00801 | 95.70% | 85.80% | 5.30% | 0.27 |
| *011 | KIR2DS4*003 | 91.30% | 65.60% | 5.00% | 0.62 | |
| *009 | KIR2DL4*00103 | 89.70% | 98.50% | 6.20% | 0.27 | |
| *007 | KIR3DL1/S1*013 | 85.90% | 98.80% | 17.50% | 0.25 | |
| *007 | KIR2DL4*00501 | 90.60% | 98.80% | 18.40% | 0.27 | |
| *007 | KIR2DS1*002 | 96.50% | 97.90% | 19.60% | 0.86 | |
| *007 | KIR2DS5*002 | 80.00% | 99.10% | 16.30% | 0.84 | |
| *007 | KIR2DL5A*001 | 74.10% | 99.10% | 15.10% | 0.8 | |
| *005 | KIR2DL4*00802 | 92.10% | 90.50% | 8.40% | 0.27 | |
| *005 | KIR2DS4*006 | 94.70% | 90.50% | 8.60% | 0.62 | |
| *005 | KIR3DL1/S1*004 | 86.80% | 90.50% | 7.90% | 0.25 | |
| *003 | KIR2DL4*00802 | 93.90% | 89.60% | 7.40% | 0.27 | |
| *003 | KIR2DS4*006 | 97.00% | 89.60% | 7.70% | 0.62 | |
| *003 | KIR3DL1/S1*004 | 93.90% | 90.10% | 7.40% | 0.25 | |
| *002 | KIR2DL4*00102 | 96.10% | 100.00% | 17.50% | 0.27 | |
| *002 | KIR2DS4*00101 | 97.40% | 97.40% | 17.70% | 0.62 | |
| *001 | KIR2DS4*003 | 95.80% | 79.60% | 21.80% | 0.62 | |
Only alleles of the previously defined central telomeric region are displayed. Other constraints were applied: Tagging must have a minimal PPV of 65%. For robustness of the estimation, only haplotypes of more than 5% were studied; haplotypewithout the KIR gene at another locus were not studied. (*) PPV and NPV drastically differ from D′. PPV and NPV are measures of association at the allelic level, whereas D′ is a locus-level average measure of LD. Confidence intervals can be computed because frequencies were estimated by gene counting. The total number of haplotype is 418 (~209 founders of the families). For example, (1st row) the probability of having KIR3DL1/S1*005 given the presence of KIR2DL4*011 is 100.0%, the probability of not having KIR3DL1/S1*005 given that KIR2DL4*011 is absent in 99.7%, the KIR3DL1/S1*005–KIR2DL4*0011 haplotype frequency is 13.6%, and D′ between KIR2DL4 and KIR3DL1/S1 is 0.21
PPV positive predictive value, the probability of the tagged KIR allele given the presence of the tagging KIR allele; NPV negative predictive value, the probability of the absence of the tagged KIR allele given the absence of the tagging KIR allele