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Position of 2A and sequences immediately upstream in the ribosome:translocon complex. In the case of polyproteins bearing an N-terminal signal sequence, the 2A oligopeptide (white ovals) and the sequences immediately upstream (grey ovals) are predicted to be located within the ribosome exit tunnel and translocon pore, respectively. The lengths ofthe exit tunnel and translocon pore, plus the lengths of pep-tides (amino acids) which may be accommodated [44–49] are also shown.
