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. 2010 Jul 8;38(20):7100–7111. doi: 10.1093/nar/gkq457

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Quantitative whole-body autoradiography. Tissue distribution in mice of two ³⁵S-labelled oligonucleotides, the 12- and 16-mer (A and B, respectively), administered i.v. Individual mice were sacrificed at 24 h post-administration, snap-frozen and sectioned for whole-body autoradiography. Following exposure the imaging plates were scanned, tissues and organs intensity were quantified by image analyses. (C) Area under the curve values normalized to the specific radioactivity of the dose levels of 16-mer (dark bars) and 12-mer (white bars).