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Duration of effect in mice. Mice were administered a single i.v. injection of saline (diamonds) or 13-mer at 0.5 (white boxes), 1 (dark boxes), 2.5 (crosses) and 5 mg/kg (circles). Livers were analyzed for (A) apoB mRNA expression normalized to GAPDH and (B) serum total cholesterol levels (both in percent of control groups) at days 1, 3, 8, 16 and 32 after administration. (Data represent mean values ± SD, n = 5).
