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. 2010 Jul 8;38(20):7100–7111. doi: 10.1093/nar/gkq457

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Multiple dosing in non-human primates. Cynomolgus monkeys were administered i.v. injections of the either saline (diamonds) or the 13-mer at 2 (dark boxes), 8 (crosses) or 32 (circles) mg/kg once a week for 28 days (arrows on figures indicates dosing days). Serum was sampled 10 days prior to first administration (Day−10) and every week from the first administration. LDL cholesterol (A), HDL cholesterol (B), ALT activity (D) in serum relative to saline control group was measured (±SD, n = 10). A subset of animals at the 8 and 32 mg/kg dose levels were kept treatment-free for an additional seven week period (n = 4). ApoB mRNA expression in liver normalized to β-actin and relative to saline control group (C) at the end of the treatment period (Day 29, ±SD, n = 6) and at the end of the treatment-free period (Day 77, ±SD, n = 4).