Table 5.
Top biological functions and canonical pathways for predicted targets of HD-deregulated miRNAs and seed region-isomiRs: IPA analysis
| P-value | No. of Molecules | |
|---|---|---|
| Top biological functions for predicted targets of HD-upreguated miRNAs and isomiRs | ||
| Disease and disorders | ||
| Genetic disorder | 1.11E-03 - 2.02E-02 | 36 |
| Neurological disease | 1.11E-03 - 4.10E-02 | 92 |
| Psychological disorders | 1.11E-03 - 1.11E-03 | 34 |
| Developmental disorder | 1.02E-02 - 2.02E-02 | 9 |
| Skeletal and muscular disorders | 2.29E-02 - 2.29E-02 | 3 |
| Molecular and cellular functions | ||
| Cellular movement | 7.59E-05 - 4.26E-02 | 24 |
| Cell morphology | 1.77E-04 - 2.82E-02 | 27 |
| Cellular assembly and organization | 2.20E-04 - 2.02E-02 | 27 |
| Cell-to-cell signalling and interaction | 3.05E-04 - 2.75E-02 | 17 |
| Cellular growth and prolifferation | 3.88E-04 - 2.29E-02 | 18 |
| Physiological system development and function | ||
| Nervous system development and function | 2.00E-05 - 4.19E-02 | 97 |
| Organ development | 3.18E-04 - 2.29E-02 | 17 |
| Tissue morphology | 6.08E-03 - 2.82E-02 | 26 |
| Organ morphology | 2.02E-02 - 2.02E-02 | 2 |
| Embryonic development | 2.29E-02 - 2.29E-02 | 3 |
| Top canonical pathways for predicted targets of HD-upreguated miRNAs and isomiRs | ||
| Axonal guidance signaling | 3.13E-07 | 79/320 |
| TGF-b signaling | 3.94E-07 | 27/70 |
| Glioma signaling | 4.11E-07 | 32/91 |
| Molecular mechanisms of cancer | 6.41E-07 | 75/304 |
| B cell receptor signaling | 7.57E-07 | 38/120 |
| Top biological functions for predicted targets of HD-downreguated miRNAs and isomiRs | ||
| Disease and disorders | ||
| Neurological disease | 9.57E-04 - 4.75E-02 | 28 |
| Developmental disorder | 8.64E-03 - 4.56E-02 | 7 |
| Genetic disorder | 2.11E-02 - 2.11E-02 | 3 |
| Skeletal and muscular disorders | 4.56E-02 - 4.56E-02 | 2 |
| Molecular and cellular functions | ||
| Cellular movement | 1.27E-04 - 4.40E-02 | 19 |
| Cellular development | 7.85E-04 - 4.42E-02 | 15 |
| Cell-to-cell signaling and interaction | 9.57E-04 - 2.43E-02 | 13 |
| Cell death | 1.41E-03 - 3.24E-02 | 24 |
| Cellular growth and proliferation | 1.51E-03 - 2.42E-02 | 13 |
| Physiological system development and function | ||
| Nervous system development and function | 8.05E-05 - 4.56E-02 | 65 |
| Organ development | 8.05E-05 - 8.05E-05 | 12 |
| Tissue development | 8.02E-04 - 8.64E-03 | 5 |
| Embryonic development | 1.97E-03 - 2.11E-02 | 8 |
| Tissue morphology | 6.39E-03 - 4.22E-02 | 17 |
| Top canonical pathways for predicted targets of HD-downregulated miRNAs and isomiRs | ||
| Molecular mechanisms of cancer | 9.65E-07 | 55/304 |
| GNRH signaling | 2.80E-06 | 27/112 |
| Renal cell carcinoma signaling | 1.05E-05 | 18/63 |
| PTEN signaling | 1.30E-05 | 21/82 |
| PPARa/RXRa activation | 1.61E-05 | 29/136 |