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. 2010 Jul 2;38(20):7179–7186. doi: 10.1093/nar/gkq584

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Schematic representation of the associative-type hydrolysis reaction catalyzed by dUTPase is shown in this figure. Stick models are based on the structures 2HQU and 1SEH conferring the ligands dUPNPP and dUMP, respectively. The TS is most probably pentacovalent and electron rich (14,25).