Table 1.
List of brain regions blocked for histologic examination
| Anatomical region Brodmann area (BA) | Regions assessed for neuritic (CERAD) plaques (silver stains) | Regions assessed for neurofibrillary (Braak) tangles (silver stains) | Regions assessed for α-synuclein lesions | Regions assessed for vascular lesions and other neuropathologies (H&E stains) |
|---|---|---|---|---|
| Middle frontal gyrus BA 46 | √+ | √+ | √ | |
| Superior & middle temporal gyri BA 22 & 21 | √+ | √+ | √ | √ |
| Inferior parietal lobule BA 39 & 40 | √+ | √+ | √ | |
| Occipital cortex BA 17 & 18 | √+ | √+ | √ | |
| Cingulate gyrus BA 24 | √ | √ | ||
| Basal ganglia and basal forebrain | √ | |||
| Entorhinal cortex BA 28 | √+ | √ | √ | |
| Hippocampus | √+ | √ | √ | |
| Thalamus | √ | |||
| Amygdala | √ | √ | √ | |
| Midbrain | √ | √ | √ | |
| Pons | √ | √ | √ | |
| Medulla | √ | |||
| Cerebellum | √ |
The √ symbol indicates the staining of tissue sections from specific regions. Those sections marked with a + are the silver-stained sections [9] used for the assessment of the frequency of neuritic plaques according to CERAD guidelines [10] and the distribution of neurofibrillary tangles according to Braak [11].