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. Author manuscript; available in PMC: 2010 Nov 11.
Published in final edited form as: Angew Chem Int Ed Engl. 2009;48(35):6448–6452. doi: 10.1002/anie.200902981

Figure 4.

Figure 4

Effect of sulindac on canonical Wnt signaling in Xenopus embryos. (a) Sulindac inhibits canonical Wnt signaling induced by Wnt3A in a concentration-dependent manner. Luciferase activity was measured in ectodermal explants dissected at the late blastula stage. Activity in the untreated control was assigned a value of 100%. Four embryos were treated with 3.5 μg/ml of sulindac; the mean ± SD is shown. The remaining data represent single embryos. (b) Sulindac attenuates canonical Wnt signaling at the level of Dvl. Values are mean luciferase activity ± SD from four independent experiments.