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. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2010 Sep 29;18(22):7809–7815. doi: 10.1016/j.bmc.2010.09.061

Table 1.

Receptor Affinities (mean ± SEM) of 1-bromo-Δ8-THC analogs 8 to 11 and 26, Δ9-THC (1) and JWH-133 (6) and JWH-229 (7).

Compound Ki (nM)
CB1 CB2 CB1/CB2
Δ9-THC (1) 41 ± 2a 36 ± 10b 1.1
JWH-133 (6) 677 ± 132c 3.4 ± 1c 294
JWH-229 (7) 3134 ± 110d 18 ± 2d 174
JWH-460 (25) > 10,000 555 ± 72 18
JWH-382 (8) > 10,000 265 ± 17 38
JWH-458 (9) 1145 ± 137 71 ± 17 16
JWH-393 (10) 1444 ± 20 28 ± 2 52
JWH-383 (11) 562 ± 21 34 ± 2 27
a

ref. 35

b

ref. 36

c

ref. 30

d

ref. 31