FIG. 3.

Immunizations with either vaccine candidate did not change Aβ plaque load in the brains of Tg2576 mice. Analysis of Aβ plaque load was performed on brain sections of transgenic mice terminated at 17–18 months of age. Preventive immunizations did not affect plaque deposition in the brains of mice from both vaccinated groups. Representative staining images of the distribution of Aβ plaques stained with 6E10 monoclonal antibody in the cortex of nonimmunized and p3Aβ_1–11-PADRE-3C3d- and p3Aβ_1–11-PADRE-immunized mice are presented. Scale bar: 200 μm at 4× magnification.