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. 2010 Sep 22;21(11):1569–1576. doi: 10.1089/hum.2009.219

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Copyright 2010, Mary Ann Liebert, Inc.

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FIG. 4. — Biochemical analysis of brain tissues revealed no changes in soluble and insoluble Aβ levels in both immunized and nonimmunized groups of Tg2576 mice. Low titers of anti-Aβ antibodies generated after immunization with p3Aβ_1–11-PADRE-3C3d or p3Aβ_1–11-PADRE were not sufficient for inhibition of both soluble and insoluble Aβ₄₀ and Aβ₄₂ peptide levels in the brain. Analysis of neuropathological changes was performed in the brains of vaccinated and control (nonimmunized) mice at the age of 17–18 months.