FIGURE 2.

Indirect calorimetry analysis of wild-type and iPLA₂γ^−/− mice on the HF diet. Oxygen consumption (VO₂), (A), carbon dioxide consumption (VCO₂) (B), respiratory exchange ratio (RER) (C), and heat generation (D) were measured in a 24-h period in wild-type (WT) and iPLA₂γ^−/− mice fed a HF diet from the time of weaning until 12 months of age utilizing an indirect calorimeter (Oxymax) as described under “Experimental Procedures.” n = 5 per group. Shaded regions represent the dark period of the 24-h cycle. WT values are indicated as solid diamonds and solid lines, and iPLA₂γ^−/− are represented with solid squares and dotted lines. Data are presented as means ± S.E. *, p < 0.05 by the Student's t test.