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Superposition of human Rabex-5 to VPS9a. Apo-form of human Rabex-5 (Protein Data Bank entry 1TXU; orange) is superposed to ARA7·GDP·VPS9a (magenta and cyan). The sequence identity between Vps9 of Rabex-5 and VPS9a is low, 27% (supplemental Fig. 3a). The root mean square deviation between 184 corresponding Cα positions of VPS9a and Rabex-5 was 1.5 Å. Possible structural shifts upon the complex formation are indicated by orange-to-cyan arrows.
