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. 2010 Sep 17;285(47):36759–36767. doi: 10.1074/jbc.M110.166231

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — FXR deficiency impairs PPARγ-induced differentiation and lipid droplet formation of primary preadipocytes. A and C, expression of adipogenic marker (A) and lipid droplet protein (C) genes in FXR^−/− when compared with FXR^+/+ preadipocytes treated with 1 μm rosiglitazone. Preadipocytes were isolated from white adipose tissue of obese FXR^−/−/ob/ob and FXR^+/+/ob/ob mice. mRNA levels were measured by quantitative PCR. Values (± S.D.) are normalized to the expression of cyclophilin and are expressed relative to those at day 0, which are arbitrarily set to 1. B, smaller size of lipid droplets in FXR^−/− when compared with FXR^+/+ preadipocytes. Representative Oil Red O staining of FXR^−/− and FXR^+/+ preadipocytes at days 0 and 8 of differentiation is shown (×20 magnification). *, p < 0.05; **, p < 0.01; ***, p < 0.001.