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. 2010 Sep 17;285(47):36759–36767. doi: 10.1074/jbc.M110.166231

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Up-regulation of the Wnt/β-catenin signaling pathway in adipose tissue of FXR^−/−/ob/ob mice and FXR^−/− MEFs. A, mRNA expression of β-catenin, LRP5, c-Myc, Axin2, and cyclin D1 in inguinal adipose tissue of FXR^−/− and FXR^+/+/ob/ob mice. mRNA levels were measured by quantitative PCR. Values are normalized to the expression of cyclophilin and are expressed relative to FXR^+/+ mice, which are arbitrarily set to 1. The results are presented as means ± S.D. B, mRNA expression of sFRP1 and sFRP5 during differentiation of FXR^−/− and FXR^+/+ MEFs treated with 1 μm rosiglitazone. C, β-catenin protein levels during FXR^−/− and FXR^+/+ MEF differentiation. D, mRNA levels of Wnt/β-catenin target genes during differentiation of FXR^−/− and FXR^+/+ MEFs. E, top, β-catenin protein levels. Bottom, mRNA levels of c-Myc, Axin2, and LRP5 in FXR^+/+ and FXR^−/− MEFs transfected for 2 days with empty of FXR retrovirus as indicated. mRNA levels were measured by quantitative PCR. Values are normalized to the expression of cyclophilin and are expressed relative to those at day 0, which are arbitrarily set to 1. The results are representative of two experiments. *, p < 0.05; **, p < 0.01; ***, p < 0.001. C.I. acid red, Ponceau S.