FIGURE 3.

Hypoglycemia and partial rescue of SIRT6 mutant mice by glucose. A, blood glucose levels in mutants (n = 41) and wild-type controls at P22 (n = 38). Mutant mice exhibit significant variation ranging from <50 mg/dL to >90 mg/dL. B and C, blood glucose (B) and body weight (C) of mice during a period from P17 to P48. D, rescue of SIRT6 lethality by feeding the mutant mice with water containing 10% glucose. E–F, blood glucose (E) and body weight (F) of mice that were supplied with water containing 10% glucose starting at P22.