TABLE 3. Subset of Genes Differentially Regulated in OVA- versus TMA-Induced Asthmaa.
| Functional classification | Gene | Affymetrix probe set ID | Ratiob OVA/OVAc | Ratiob TMA/TMAc |
|---|---|---|---|---|
| Chemokines and cytokines | Ccl2 (MCP-1) | 102736_at | 2.21 | 1.02 |
| Ccl11 (eotaxin) | 92742_at | 1.91 | 0.93 | |
| Cxcl13 | 102025_at | 1.78 | 1.20 | |
| Ccl7 (MCP-3) | 94761_at | 1.67 | 1.05 | |
| Ccl12 (MCP-5) | 93717_at | 1.47 | 1.14 | |
| Socs1 (suppressor of cytokine signaling 1) | 92832_at | 1.37 | 0.95 | |
| Cxcl9 (Mig) | 101436_at | 1.31 | 1.12 | |
| Ccl17 | 97783_at | 1.30 | 1.09 | |
| Il1r2 (interleukin 1 receptor, type II) | 161689_f_at | 1.21 | 1.07 | |
| Pglyrp (peptidoglycan recognition protein) | 104099_at | 1.03 | 0.51 | |
| Pglyrp (peptidoglycan recognition protein) | 162475_f_at | 0.96 | 0.38 | |
| Cxcl12 (SDF-1) | 100112_at | 0.79 | 1.09 | |
| Secretion and remodeling | Sprr2a | 101024_i_at | 13.00 | 0.80 |
| Gob-4 (Agr2) | 101075_f_at | 3.83 | 1.09 | |
| RELM beta | 93755_at | 3.21 | 1.08 | |
| Sprr2b | 99701_f_at | 2.50 | 0.91 | |
| Sprr2a | 101025_f_at | 2.40 | 0.91 | |
| Scinderin | 103715_at | 2.27 | 1.04 | |
| pIgR | 99926_at | 1.81 | 0.74 | |
| Timp1 | 101464_at | 1.52 | 1.1 | |
| Cathepsin B | 94831_at | 1.36 | 1.13 | |
| Sfrp2; secreted frizzled-related sequence protein 2 | 93503_at | 1.35 | 1.12 | |
| Col3a1 (collagen) | 98331_at | 1.34 | 0.86 | |
| Cathepsin E | 104696_at | 1.33 | 1.13 | |
| Tfpi2 (tissue factor pathway inhibitor 2) | 94383_at | 1.26 | 1.08 | |
| Niemann Pick type C2 | 160344_at | 1.09 | 1.31 | |
| Stxbp2 (syntaxin binding protein 2) | 101398_at | 1.05 | 1.22 | |
| Vamp8 | 93305_f_at | 0.93 | 1.21 | |
| Krt2–7 (keratin) | 97920_at | 0.83 | 1.11 | |
| Cell adhesion and lectins | Intelectin | 102755_at | 3.07 | 1.02 |
| A430096B05Rik (Fc fragment of IgG binding protein) | 97826_at | 2.60 | 1.11 | |
| Vcam1 | 92559_at | 1.39 | 1.09 | |
| Vcam1 | 92560_g_at | 1.37 | 1.20 | |
| Col3a1 (collagen) | 98331_at | 1.34 | 0.86 | |
| Klra3 (killer cell lectin-like receptor) | 93894_f_at | 0.98 | 1.23 | |
| Sh3d4 (SH3 domain protein 4) | 98848_at | 0.96 | 0.77 | |
| Jup (junction plakoglobin) | 104121_at | 0.88 | 0.71 | |
| Complement | Properdin | 101468_at | 1.52 | 1.13 |
| Daf2 (decay accelerating factor 2) | 92198_s_at | 1.35 | 1.02 | |
| Arginine metabolism | Arg1 (arginase 1) | 93097_at | 4.27 | 1.15 |
| Ddah2 | 92887_at | 0.91 | 1.20 | |
| Nos3 (endothelial Nitric Oxide Synthase) | 94167_at | 0.95 | 0.83 |
a
Experimental/control ratio is >1.2 or <1/1.2 (0.83).
b
Ratio of relative change in chip intensity as depicted in Figure 3.